THE RELATIONSHIP OF THE LIPID

PROFILE WITH THE SEVERITY OF

STENOSIS IN CORONARY ARTERY
DISEASE PATIENTS

THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS
THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS

ABSTRACT
Introduction Disruption of lipid profile which is characterized by an increase in total
cholesterol, Low Density Lipoprotein (LDL), triglycerides, low value of High
Density Lipoprotein (HDL) increases the risk of CAD.

Method This is a retrospective study with data collection from inpatients at Prof. RSUP.
Dr. R. D. Kandou Manado from December 2021 to May 2022. Data analysis used
the IBM SPSS Statistics 25 program with Pearson and Spearman tests.

Result No significant relationship : between HDL and Gensini's score (p value =

0.909), triglycerides to Gensini's score (p value = 0.061), and total cholesterol to
Gensini score (p value = 0.122).
Significant relationship : between LDL and Gensini score (p value < 0.05).

Conclusion There is a significant relationship between LDL and Gensini score in coronary
heart disease.
 INTRODUCTION

Risk factors for coronary heart disease : age, education level, family income, diet,
exercise, smoking, excessive drinking, and elevated blood pressure and glucose

Major risk factors of cardiovascular disease : increased total cholesterol (TC) and low-
density lipoprotein (LDL-C) cholesterol and decreased levels of high-density lipoprotein
(HDL-C) cholesterol

Aim of this study : assess the relationship between lipid profile and severity of stenosis in
patients with coronary artery disease

THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS
 METHODS

Subject Location & Time Data Characteristic

Using a retrospective design
involving patients aged > 40 years
with risk factors for hypertension,
diabetes mellitus, smoking, and a
family history of CAD.
Internal Medicine Room at Prof Age, gender, BMI and CAD risk
DR. R. D. Kandou Manado from factors were recorded as the basic
December 2021 to May 2022 data characteristics

Data Processing
Using SPSS version 21.0 to
obtain frequency tables and cross
tables according to research
objectives
Data Analyzing
o Using Chi-square and fisher-exact statistical
tests with a significance level of p < 0.05 with
a 95% confidence level.
o LDL, HDL, triglycerides and total cholesterol
was analyzed for its correlation with the
Gensini score.

THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS
 RESULT
Total Cholesterol P Value
Variable <200 mg/dl ≥ 200 mg/dl 0,667*

Characteristics CAD Risk Factors

(n=24) (n=16)

of Subjects Hypertension, n(%)

Yes 17 (70,8) 10 (62,5)
0,436*

No 7 (29,2) 6 (37,5)

Diabetes mellitus, n(%) 0,182*

Total Cholesterol P Value Yes 12 (50,0) 6 (37,5)
Variable <200 mg/dl ≥ 200 mg/dl 0,667* No 12 (50,0) 10 (62,5)
(n=24) (n=16)
Smoking, n(%) 0,057**
Gender, n(%)
Yes 17 (70,8) 8 (50,0)
Male 22 (91,7) 14 (87,5)
No 7 (29,2) 8 (50,00
Female 2 (8,3) 2 (12,5)
Age, n(%) 0,193* Menopause, n(%) 0,154*
<40 years 0 (0) 0 (0) Yes 0 (0) 3 (18,8)
>40 years 24 (100) 16 (100) No 24 (100) 13 (81,3)
BMI, n(%) 0,581*
Family History with CAD, n(%) 0,729**
Underweight (<18,5 kg/m2) 0 (0) 0 (0)
Yes 11 (45,8) 11 (68,8)
Normal (18,5-24,9 kg/m2) 10 (41,7) 5 (31,3)
No 13 (54,2) 5 (31,3)
Overweight (25,0-29,9 kg/m2) 14 (58,3) 9 (56,3)
Obese I (30,0-34,9 kg/m2) 0 (0) 2 (12,5) Statin Medication, n(%) 0,667*
Obese II (>35,0 kg/m2)) 0 (0) 0 (0) Yes 16 (66,7) 12 (75,0)
No 8 (33,3) 4 (25,0)

Gensini Score, mean ± SD 54,42 ± 41,23 78,13 ± 36,88 0,071***

THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS
 RESULT
LDL
Correlation Triglycerides
Correlation
Gensini Score

and

Gensini Score
and Gensini
Gensini Score
Score

LDL Triglycerides

HDL Total
Correlation Cholesterol
Gensini Score

Gensini Score
and Correlation
Gensini and Gensini
Score Score

HDL Total Cholesterol

THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS
THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS

DISCUSSION

Subject’s Cross-sectional & Research by Wang

Characteristic Longitudinal Studies et al
• Total cholesterol TC, LDLC, and TG The majority of
> 200 mg/dL concentrations are dyslipidemic
• Over 40 years old positively associated patients are male
male with age

Analysis of Research by Research by Jongseok

This Study
Risk factors of CAD
with total cholesterol
levels were NOT
statistically related
Volsky et al
Hypertension, diabetes
mellitus and family history
of CAD were significantly
associated with total
cholesterol levels
Lee et al
Hypertension, diabetes
mellitus, smoking and
family history of CAD were
significantly associated
with total cholesterol levels
THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS

DISCUSSION

Average Gensini score This study : LDL scores were significantly associated with a positive
weak correlation with Gensini score. HDL scores, triglycerides and total
Total cholesterol < 200 mg/dl = 54.42 ± 41.23 cholesterol were NOT significantly associated with a positive very weak
Total cholesterol ≥ 200 mg/dl = 78.13 ± 36.88 correlation with Gensini score.

Avci The Gensini score is related to the

et al severity of carotid stenosis Sawengi LDL variable and Gensini score have a negative
et al correlation

The average patient with total Sung Woo Kwon

Gensini score is not significantly related to LDL variable
Charach et et al & Kai-Yang
cholesterol > 200 mg/dL had an average Wang et al
al
genesis score of 66.7
Devina There is no relationship between LDL and coronary
The mean total cholesterol in his study et al artery stenosis
Kurmus et
was 198.5 mg/dL and the Gensini score
al This Study & High LDL levels are significantly associated with the
was 25.3 ± 39.6
Jin et al severity of coronary heart disease
THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS

DISCUSSION
An increase in LDL-C levels is associated with an increased risk of cardiovascular events HDL can improve endothelial
A decrease in LDL-C is associated with a reduced prevalence cell dysfunction, stimulate the
production of prostacyclin,
inhibit endothelial cell
Aimei Jia et al & Sudjana et al : Triglycerides were significantly apoptosis, reduce platelet
related to the Gensini score aggregation, and inhibit LDL
oxidation

Triglycerides increase the risk of CAD by increasing LDL levels,

lowering HDL levels, impairing arterial wall function, and activating Cause of Different Results
thrombogenic factors and plasminogen activators
Samples Range
The number of The range of this
This study is supported by Faisal et al and Kai et al : there was NO samples in this study is quite
relationship with Gensini score in patients with CAD study was limited short
THE RELATIONSHIP OF THE LIPID PROFILE WITH THE SEVERITY OF STENOSIS IN CORONARY ARTERY DISEASE PATIENTS

CONCLUSION

There is a significant
relationship between LDL
and Gensini score in
coronary artery disease