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Thyroid and Antithyroid Drugs-1
Thyroid and Antithyroid Drugs-1
ANTITHYROI
D DRUGS
DR.AMMARA BUTT
Pharmacology
• Pituitary
• Thyroid
• Parathyroid
• Ad. Cortex
• Ad. Medulla
• Pancreas
• Ovaries
• Testes
Thyroid secretes 2 types of hormones:
• iodine-containing amino acids (thyroxine and triiodothyronine)
• and a peptide (calcitonin)
DIT + DIT = T4
MIT + DIT = T3
Proteolysis causes Release of T4 and T3 from thyroid gland
Also has a growth-promoting effect that causes thyroid cell hyperplasia and
an enlarged gland (goiter)
Thyroid hormones bind to intracellular receptors that control the expression of genes
responsible for many metabolic processes
Methimazole
Propylthiouracil (PTU)
These salts also decrease the size and vascularity of the hyperplastic thyroid
gland
Amiodarone
Iodine-containing antiarrhythmic drug
can cause hypothyroidism through its ability to block the peripheral conversion of T4 to T3.
Iodinated radiocontrast media
oral diatrizoate and intravenous iohexol