Low dose bioequivalent curcuminoids

Turmeric
extract.
Used across multiple therapeutic categories
An extremely well-known ingredient; fastest
growing in the dietary & food supplement
space.
Joint Health
More than 8000+ Publications of Clinical Trials,
Articles and Reviews.

Brain Health

Skincare & Personal Care

Sports Nutrition

Liver Health
 Water Insoluble &

Current issues with

low bulk density

turmeric extract.
Low bioavailability

Lacks the availability to be

differentiated - Low level of novelty

High volume but low number of

quality studies done
1. Standard turmeric extract
2. Turmeric extract with blended turmeric oil
3. Phytosomal turmeric extract
4. Turmeric extract with synthetic carriers and surfactants

Large daily dosage

Introduces Turmeric extract powder 60N

Standardized to 60%
Curcuminoids

All-natural product

High dissolution =
High bioavailability
> Low dose required
Advantages.
Unlock the Natural potential
of Turmeric Naturally

Higher Convenience for

formulator and to consumer

Water Dispersible + Higher Dissolution

= Instant dispersion

Highest Curcuminoid Content

(60% Total Curcuminoids)

All Natural (no chemical Excipients, no Synthetic

surfactants, excipients are part of natural diet)

Clinically Substantiated for lower dose*

*Comparative human PK study.

Clinical Package:
Animal Study.
Pre-Clinical Animal Study

Pharmacokinetic Study compares ADME of TurmXTRA®60N with

Standard Turmeric Extract. Dose of 300 mg / kg of curcuminoids
in Rats (2 groups); Standard v/s TurmXTRA®60N . Comparison of
AUC, Tmax and Cmax.

Result
Curcumin detected crossing the blood brain barrier.

Brain Uptake Study

To test the ability of TurmXTRA®60N to deliver Free Curcumin

across the Blood Brain barrier.

Result
Curcumin detected crossing the blood brain barrier.

These statements have not been evaluated by FDA.

This product is not intended to diagnose, treat, cure, or prevent any disease.
Clinical
Package.
Comparative Human PK Study 1
Pharmacokinetic Study of TurmXTRA®60N with
Standard Turmeric Extract in Healthy Human

Average Concentration (ng/mL)

Volunteers.

Study comparing 150mg of curcuminoids from Effective concentration

TurmXTRA®60N (250mg) with 1500mg of
curcuminoids from Standard Turmeric Extract -
95% Curcuminoids (1575mg).

Comparison of AUC, Tmax and Cmax.

Results
• Comparable kinetics at 10 times lower dose Time (Hrs) T R
as that of standard turmeric extract (95%).
• Superior concentration.
• Effective concentration for longer duration. T Test Product R Reference Product
• Superior Predictability in the kinetics
(Lesser inter subject variability).
These statements have not been evaluated by FDA. This
product is not intended to diagnose, treat, cure, or
prevent any disease.
Clinical
Package.
Comparative Human PK Study 2
Pharmacokinetic Study of TurmXTRA®60N with
Standard Turmeric Extract in Healthy Human

Average Concentration (ng/mL)

Volunteers.
Effective concentration

Study comparing 150mg of curcuminoids from

TurmXTRA®60N (250mg) with 1500mg of
curcuminoids from Standard Turmeric Extract -
95% Curcuminoids (1575mg).

Comparison of AUC, Tmax and Cmax.

Results
• Comparable kinetics at 10 times lower dose Time (Hrs) T R
as that of standard turmeric extract (95%).
• Superior concentration.
• Effective concentration for longer duration. T Test Product R Reference Product
• Superior Predictability in the kinetics
(Lesser inter subject variability).
These statements have not been evaluated by FDA. This
product is not intended to diagnose, treat, cure, or
prevent any disease.
 Human
Clinical Clinical Study 1

Average Concentration (ng/mL)

Package Effective concentration

Conclusion.
These conclusions are drawn from
the two Human PK studies.

Time (Hrs) T R

Human
Clinical Study 2

Average Concentration (ng/mL)

Effective concentration

T Test Product R Reference Product

Time (Hrs) T R
Clinical Package
Conclusion.
Human Clinical Study 1 Inference

TurmXTRA®60N, exhibited higher rate of absorption and comparable TurmXTRA®60N can be reported as having
extent of absorption for Total curcumin, Total Curcuminoids and exhibited BIO EQUIVALENCE* to standard 95%
Tetrahydrocurcumin from a 10 times lower dose as compared to turmeric extract, and therefore, is expected to be
Standard Turmeric Extract (95% Curcuminoids). equally effective in various clinical conditions
including joint health and liver health with one tenth
TurmXTRA®60N achieves Cmax relatively earlier than Cmax of the dose of standard turmeric extract.
Standard Turmeric Extract 95%; thus my have faster onset of action.

TurmXTRA®60N shows consistent response across all subjects in

both trials as compared to Standard Turmeric Extract 95%.

Higher degree of Inter subject variability is observed in subjects

consuming Standard Turmeric Extract 95%.

* Standard definition of bioequivalence applied to nutraceutical ingredient to get “absence of a significant difference
in the extent to which the active ingredient in nutraceutical alternatives becomes available at the site of action when
administered under similar conditions in an appropriately designed study
Clinical Package:
Clinical trials
Human trials
(ongoing)
Joint Health Liver Health

These statements have not been evaluated by FDA. This

product is not intended to diagnose, treat, cure, or
prevent any disease.
6x stronger

6 x Standard 95% Turmeric Extract

≈
250mg | Single Dose 1500mg | 3 doses

*Based on upcoming clinical trial These statements have not been evaluated by FDA.
This product is not intended to diagnose, treat, cure, or
prevent any disease.
Clinical Package: Why choose TurmXTRA®60N?

Clinical trials
Smaller Doses
Improves convenience & enhances compliances for
customers reducing size & number of capsules
Unlock the Natural potential of
Turmeric Naturally
Flexibility
Conclusive, Data backed Bioequivalence* showcased by More space in tablets and Capsules for other ingredients
Pharmacokinetic Studies with analysis of Plasma of Healthy Human
volunteers allows for:
Improved Profitability
Smaller dose requirements allow higher margins at same
daily cost to consumer

Water Dispersibility
Increases the type of Applications - Shots, Sachets, Powders

All Natural
Improves your product Naturally. No synthetic excipients or
Surfactants

* Standard definition of bioequivalence applied to nutraceutical ingredient to get “absence of a These statements have not been evaluated by FDA.
significant difference in the extent to which the active ingredient in nutraceutical alternatives This product is not intended to diagnose, treat, cure, or
becomes available at the site of action when administered under similar conditions in an prevent any disease.
appropriately designed study