ANTIMALARIALS

STRUCTURE–ACTIVITY RELATIONSHIP
-N'-(7-chloroquinolin-4-yl)-N,N-diethylpentane-1,4-diamine
 Amodiaquine HCl

4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)methyl]phenol
Use: It is used for suppressing P. vivax and P. falciparum infections being 3–4 times
more active than quinine.
 Primaquine

used as an antimalarial agent

N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

Pamaquine

N,N-diethyl-N'-(6-methoxyquinolin-8-yl)pentane-1,4-diamine

used as an antimalarial agent.

Quinacrine

N′-(6-Chloro-2-methoxy-acridin-9-yl)-N,N-diethylpentane-
1,4-diamine

Proguanil

1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine

Pyrimethamine

for the prevention of severe attacks due to P.

falciparum and P. vivax.
 Artemether

10-methoxy-3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino-2-benzopyran

Artesunate

It is used as an antimalarial agent.

3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino-2-benzopyran 10yl butandi oic

acid
Mefl oquine

1
2
5
4 3
6
2
7 8
1

2,8-Bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol

It is used as an antimalarial agent.