Single-Cell Multiomics

SaaS Workbench Systems

for Genomics Research
Definition

 Multiomics involves the analysis of datasets from multiple omics approaches, such as
genomics, proteomics, transcriptomics, epigenomics, metabolomics, and microbiomics
 Recent technological advancements enable single-cell multiomics analysis, offering a
detailed understanding of cell activity and disease pathophysiology
Importance

 Single-cell multiomics explores beyond genetic information, providing insights into gene
regulation, transcription, translation, and phenotypic molecular mechanisms
 Applications in cancer, rare diseases, cell biology, synthetic biology, and precision
medicine
Business Impact

 Exposure of complex relationships between the different layers of biological information

and the connections between structural and functional information, giving insight into
disease pathophysiology
 Accelerates cell and gene therapy program development and production
 The development of preventative treatments for disease, a core tenet of personalized
health.
Drivers

 Correlation of data from different omics experiments advances molecular biology,

supported by initiatives like the Human Cell Atlas and precision medicine
 Rapid advances in multiomics instrumentation, biochemistry, automation, and
bioinformatics
 Availability of reagents, instruments, and CRO services for single-cell multiomics
 Vendors developing solutions to handle large datasets and integrate multiomics data
 We expect there will be substantial optimization of multiplex omics systems and end-to-
end vendor platform solutions in the next three years
Obstacles

 Limited availability of end-to-end solutions hinders multiomics research

 Challenges in configuring the right sequence of analyses due to varying requirements of
omics methodologies
 Overwhelming large datasets and complexity when combining multiple omics
technologies

 Sample Vendors
10x Genomics; BD; Bio-Rad; Govita Tech; Mission Bio; My Intelligent Machines;
NanoString; OmniTier; Takara Bio; Thermo Fisher Scientific
SaaS Workbench for
Genomics Research
Definition

 A SaaS workbench for genomics research combines cloud computing and a suite of
bioinformatics tools for genomic data analysis and discovery
 Genomics data analysis is computationally intensive and complex, involving multiple
tools and reference datasets in various data transformation and visualization stages
 SaaS workbenches assist researchers in managing, analyzing, and visualizing genomics
data efficiently
Importance

 Genomics research demands a complex ecosystem of tools, technology, computational

power, and data management
 SaaS workbenches offer scalable computational resources to process and analyse
experimental data across multistep pipelines
Business Impact

 SaaS workbenches add value in various ways, including support for data pipelines,
improved collaboration, dynamic workflow scaling, and enhanced infrastructure security
 They enable integration of multiple data types, supporting initiatives like multiomics
research
 More secure and reliable infrastructure via big cloud vendor services
Drivers

 Next-generation sequencing (NGS) technology leads to larger datasets and the need for
advanced tools and streamlined processes
 Maturation of analysis workflow platforms simplifies data manipulation and analysis for
non-programmers
 Collaboration with leading cloud providers facilitates genomics workflow support
 Advancements in omics technologies and the pressure for reproducibility drive
workbench updates
 Data analytics, including AI techniques such as machine learning, now have great
potential to aid in new discoveries leveraging that data
Obstacles

 Complexity of installing, customizing, and maintaining genomics tools and platforms.

Requires high level of ongoing maintenance to keep the software, data and hardware up to
date
 High upfront investment in hardware and expertise
 Bias toward existing vendors and interoperability challenges
THANK YOU