Presentation by Chilaka Ifeanyi

Essential nutrients for your health

&
 MAGNES DIRECT & MAGNES ACTIVE

CONTENT
 Introduction of Denk Pharma
 Introduction of Magnesium
 Key benefits of Magnesium:
 Bone formation
 Nerves Function
 Muscles Function
 Heart Function & Blood Pressure Control
 Cramps Prevention
 Migraines Prevention
 Diabetes Control

 Magnesium Defeciency & Groups at risk

 Product Presentation/Information
 Conclusion & Key Messsage
 WHO IS DENK?

Denk Group is a global company with core

competence in pharmaceuticals (Denk Pharma), food
supplements (Denk Nutrition), and Health Ingredients
(Denk Ingredients).

Our products cut across all areas of medicine and they

are all manufactured in Germany.

Some of our products include:

 1. Introduction

• Even though the human body contains only 20 – 30 g magnesium, this mineral is the
fourth most abundant in the body and plays many important roles in the body. 1

• Magnesium is a cofactor in more than 300 enzyme systems that regulate diverse
biochemical reactions in the body, including protein synthesis, muscle and nerve
function, blood glucose control and blood pressure regulation. 2, 3, 4

• The human body cannot produce magnesium itself and is therefore dependent on its oral
supply.

• Magnesium is called the “bone and muscle mineral“, because over 60% of intracellular
magnesium is located in the bone tissues, the rest in muscles and other body cells.

• The recommended amount of magnesium is 300mg-420mg daily.

 2. Key Benefits

 BONE FORMATION

 About 60% of total magnesium is stored in bones.

 Besides calcium, magnesium plays a significant role in the
maintenance of bones and teeth since it functions as counterpart
to calcium and affect bone formation and maintenance.
 Calcium to magnesium ratio is 2:1
 Scientific evidences show that there is a positive association
between magnesium intake and mineral density.

 Therefore, an adequate magnesium supply is very important for healthy bones.

 It also prevents the onset of osteoporosis

 8. Bone health and osteoporosis

• Two types of bone cells are mainly involved in bone metabolism: 9

1. Osteoclast: 2. Osteoblast:
A type of bone cells that resorbs A type of bone cell that is responsible
bone using acid and enzymes. for the production of bone and bone
formation.

Bone resorption Bone formation

• Bone itself undergoes continuous remodeling with constant resorption and

disposition of calcium into new bone.
 8. Bone health and osteoporosis

• During childhood, bone formation outpaces resorption as growth proceeds.

• After skeletal maturity is reached, bone resorption and formation maintain
an approximate balance. 3
Mg
•

Calcium
Calcium
Osteoblasts: creating bone
Osteoclasts: destroying bone

The balance between bone resorption and deposition changes with

age
→ osteoporosis can develop, when bone resorption exceeds bone
formation
m
 3. Key Benefits

 NERVE FUNCTION

Magnesium is of special significance for the normal

functioning of the system.

If affects optimal nerve transmission and neuromuscular

coordination.

It contributes to the proper transmission of signals and

messages throughout the nervous system.
 There is an increased stimulation of nerve cells, owing to magnesium deficiency.

 Magnesium plays a very important role in the protection of nerves against excessive excitation
 4. Key Benefits

 MUSCLE FUNCTION

The role of magnesium in muscle function cannot be

over emphasized.

 It is very essential for normal energy metabolism.

 Magnesium is important for maintenance of normal muscle contraction and relaxation

 5. Key Benefits

 HEART FUNCTION

Magnesium is important for cardiac energy metabolism.

Magnesium is important for the maintenance of normal
cardiac muscle contraction and relaxation. Hence,

 It is involved in regulation and control of blood pressure

 Prevention of cardiovascular diseases.

 6. Key Benefits

 CRAMPS PREVENTION

Leg cramps are commonly reported among:

• Pregnant women
• Older adults
• Athletes

 Magnesium plays a role in neuromuscular transmission and

 Therefore, magnesium supplementation plays a significant role in reducing leg cramps in
adults.
muscle contraction.
 7. Key Benefits

 MIGRAINE PROPHYLAXIS

Nearly 20% of neurological disorders in the United States

have been linked to hypomagnesaemia.

 Significant lower levels of magnesium have been reported

in people with migraines

Magnesium have been shown to:

• Prevent migraine
• Improve life quality
 It is suggested that 600mg of magnesium daily may be efficient in migraine
• Reduce migraine days between 22-43%
prophylaxis
 8. Key Benefits
MAGNESIUM AND DIABETES

• Magnesium is involved in glycolysis and blood glucose control. 2, 3, 4

• Several studies have shown an inverse relationship between low serum magnesium
levels and incidence of type 2 diabetes mellitus. 15, 24, 25

• Higher dietary magnesium intake is associated with a lower risk of developing type 2
diabetes mellitus and metabolic syndrome. 15, 24, 25

Oral magnesium supplementation could reduce plasma glucose levels and improve the
glycemic status in randomized controlled trials (RCTs) involving adults with prediabetes
and diabetes. 26, 27
 9. MAGNESIUM DEFICIENCY & GROUPS AT RISK

GROUPS AT RISK OF MAGNESIUM INADEQUACY

People with gastrointestinal diseases 1

• Chronic diarrhea and fat malabsorption resulting e.g. from Crohn’s disease,
celiac disease or reginal enteritis can lead to magnesium depletion,
malabsorption or loss.

People with type 2 diabetes 1

• Magnesium deficits and increased urinary excretion can occur in people with
insulin resistance and/or type 2 diabetes.
• The magnesium loss appears to be secondary to higher concentrations of
glucose in the kidney that increase urine output.
 10. MAGNESIUM DEFICIENCY & GROUPS AT RISK

GROUPS AT RISK OF MAGNESIUM INADEQUACY

Older adults 1
• Older adults have lower dietary intakes of magnesium than younger adults.
• In addition, magnesium absorption from the gut decreases and renal
magnesium excretion increases with age.

People with alcohol dependence 1

• Magnesium deficiency is common in people with chronic alcoholism.
• In these individuals, poor dietary intake and nutritional status and
gastrointestinal problems can all contribute to decreased magnesium status.
 11. Target groups

Magnesium recommendations 2
Target group Recommendation 2 300 mg
magnesium
Pregnant women > 19 years 310 mg/d
Breastfeeding women > 19 years 310-320 mg/d
Women > 19 years 310-320 mg/d
Migraine prophylaxis 600 mg/d
 12. Target groups

Magnesium recommendations 2
Target group Recommendation 2 400 mg
magnesium
Men > 14 years 400 – 420 mg/d
Women 14 – 18 years 360 mg/d
Pregnant women 14 – 18 years 400 mg/d
Breastfeeding women 14 – 18 years 360 mg/d
 13. Target groups

Further groups with increased magnesium requirements 1

People with physical or mental stress Physically active people

Older adults People on a diet

14. PRODUCT PRESENTATION

Essential nutrients for your health

400mg

&
300mg
 15. Product Information

Product Content of Blister Appearance Shelf life Pack

magnesium pack size

magnes 400 mg Direct White granule 3 years 30

direct Denk sticks

magnes 300 mg Direct Pink granule 3 years 30

active Denk sticks
 16. Product Information

Product Content of Duration of Age recommendation Suitable for

magnesium intake diabetics

magnes 400 mg As required Aged 12 years and Yes

direct Denk above

magnes 300 mg As required Aged 12 years and Yes

active Denk above
 17. Posology & Administration

INGREDIENTS
Product Composition Per daily intake % of recommended
(= 1 direct stick) daily requirement
magnes active Denk Magnesium* 300 mg 80 %

magnes direct Denk Magnesium* 400 mg 107 %

* Magnesium= Magnesium oxide

 Fast absorption of magnesium and fast supply of muscle, heart and nerves

INTAKE
• The recommended intake is 1 stick per day
• Easy consumption - without water
 18. Conclusion / Key Message

• Everybody needs magnesium because it fulfills numerous

important functions within the body.

• The human body cannot produce magnesium itself and is

therefore dependent on its oral supply.

• The more active we are, the more magnesium we need.

&
… support an active lifestyle!
… supply heart, nerves and muscles with magnesium.
HEALTHCARE MADE IN GERMANY
since 1948
THANK YOU