URIC ACID METABOLISM AND

LABORATORY TEST
Liong Boy Kurniawan
Clinical Pathology Department
Hasanuddin University
Makassar
 Uric acid product catabolism 
purine (adenosine and guanosine)
 Purines catabolism dietary and
endogenous nucleic acid.
 Daily synthesis rate approximate
400 mg
 Dietary contribute another 300 mg.
 Net urinary excretion of uric acid is
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 Renal handling of uric acid :
 (1) glomerular filtration
 (2) reabsorption proximal tubule
98% -100%
 (3) subsequent secretion lumen in the
dista l portion of the proximal tubule;
 (4) further reabsorption in the distal
tubul e.
6% to 12% o the amount filtered.
Liong Boy Kurniawan- UNHAS TEACHING HOSPITAL, MAKASSAR 2
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 Hyperuricemia defined by serum uric acid > 7.0 mg/dL

in men or >6.0 mg/dL in women.
 Asymptomatic hyperuricemia  requently detected
through screening
 Long-term of follow-up asymptomatic hyperuricemic
 at risk  kidney disease & gout

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06/02/2024 RDN PAKASI - UNHAS TEACHUNG HOSPITAL, MAKASSAR 5
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 Methods for measuring uric acid:

 Phosphotungstic Acid methods
 Uricase Methods
 HPLC methods

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Reference Intervals:
 enzymatic method 
 3.5 to 7.2 mg/dL for males
 2.6 to 6.0 mg/dL for females
 Concentration of serum uric acidincreases gradually
with age
 A rise in women  after menopause reaches similar
to men.
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 THANK YOU

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