Tetralogy
METHODS
of Fallot
By
SRI LEKHA.S.K
ROLL NO: 92
 Tetralogy of Fallot is characterised by the presence of a
ventricular septal defect, overriding aorta, right ventricular
outflow tract obstruction and right ventricular hypertrophy.
 Tetralogy of Fallot is one of the commonest cyanotic heart
defects.
 The severity of cyanosis is determined by the degree of
obstruction to pulmonary blood flow.
 Prevention of cyanotic spells is key for safe anaesthesia.
 Late complications include arrhythmias, pulmonary
regurgitation and right heart failure.
By reading this article, you should be able to:
 Describe the anatomy and pathophysiology of
tetralogy of Fallot.
 Create a plan for the prevention and treatment of
a cyanotic spell.
 List the common complications seen in later life
after tetralogy of Fallot repair.
 State the risks of anaesthesia in the pre- and
postoperative periods for a patient with repaired
tetralogy of Fallot.
CHD is found in approximately 1% to 1.2% of live
births. TOF is the most common cyanotic CHD, with
a nearly equal sex distribution, a prevalence of 1 out
of 3,000 births, and an incidence of 5 to 7 out of
10,000 live births. TOF represents 5% to 7% of all
CHD. Medical and surgical advances have allowed an
increased prevalence of CHD among older children
and adults, with a current estimated adult CHD
patient US population of approximately 1 million, of
which an estimated 15% are TOF patients. In contrast,
without surgical intervention, survival decreases as
the patient ages. Patients with unrepaired TOF
have an estimated survival rate of 66% at 1 year of
age, 40% at 3 years, 11% at 20 years, 6% at 30 years,
and 3% at 40 years.
MATERIALS AND
Infant of age group of 3 month to 6
month
: Single-centre, hospital-based, cross-
sectional pilot study .
Any infant between the age
group 3 month to 6 month diagnosed with fallot visiting
outpatient department, emergency, or admitted during the
study time frame is to be enrolled, whereas those who are
high risk of getting fallot i.e. include arrhythmias,
pulmonary regurgitation and right heart failure
1000 infants of age group 3
month – 6 month.
The study is to be conducted over a
period of one year .
Varient calling,filter variety based on
quality ,rescale probabilites checked , binoimial test, B-H FDR, puring
method, subset to gene set probability, greedy step down correleation.
: Informed
consent parents to be obtained prior to recruitment in the study
and approved by National Healthcare Group domain specific
review board ethics committee. Consent was obtained by all
participants in this study
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