Large intestine tumors

Dr Shahid Hussain Mirani

Tumors
-Adenocarcinoma
-Polyposis
-Lipoma
-Leiomyoma
-Gastrointestinal Stromal tumor
-Leiomyosarcoma
-Angiosarcoma
-Kaposi sarcoma
Adenocarcinoma

- 2nd most cause of death in world

- 5 years survival is 55%
- Most lethal and curable disease of western countries
- Preventive and highly curable disease if detected early
- Screening program are going on large scale
Risk Factors

- Diet ….red meat, Animal fat, Increased cholesterol in Stool

- Folate is protective
- Calcium supplement
- Fiber supplement
- Alcohol consumption
Morphology

- Fungating
- Ulcerative
- Annular
- Tubular
Symptoms

- Altered Bowel habits

- Blood in stool
- Diarrhea, Constipation and feeling of improper emptying
- Abdominal discomfort
- Narrowing of stool
- Weight loss
- Constant Fatigue
Management

- Proper History
- Physical Examination
- CBC, Faecal occult blood, LFT, CEA
- Colonoscopy
- Barium Enema
- CT Scan Abdomen
- Biopsy
Treatment

- Curative Surgery
- Conventional, Laparoscopic, Endoscopic, Robotic
- Palliative Surgery
- Chemotherapy
- biotechnology has opened a new window in CRC diagnosis and treatment by introducing
different application of antibodies, antibody fragments, non-Ig scaffold proteins, and
aptamers in targeted therapy and drug delivery
THANKS