• Quality control test for rubber closures, • Quality control test secondary packing materials Quality control tests for Glass containers 1) Chemical resistance test • Powdered Glass test • Water attack test 2) Hydrolytic resistance test 3) Arsenic test 4) Thermal shock test Types of Glass Containers 1) Type-1 Glass Container It is used as a packaging material for lot of parenteral and non- parenteral preparations. It can also be used to store strong alkali and acids – (Borosilicate glass)
2) Type-2 Glass Container
It is suitable for strong neutral aqueous preparations and acidic preparations (Treated Soda Lime Glass)
3) Type-3 Glass Containers
It is used as a packaging material for non- parenteral preparations and for packaging certain parenteral preparations (Regular Soda Lime Glass)
4) Type-4 Glass Containers
It is used for storage of oral dosage forms and topical products (General Purpose Soda Lime Glass) Hydrolytic Resistance Test Contd….. Arsenic test Contd…. QUALITY CONTROL OF COLLAPSIBLE TUBES 1)LEAKAGE TEST : Water was filled in the tube and tightly closed. External surface was wiped off and tube is kept inverted on filter paper at base. Allow to stand for 1hr.Filterpaper shows absorption at any time during test period. 2)LACQUER CURING TEST : A) Power of adhesion: Tube was spitted along the length and flattened. Cotton wool soaked in acetone was rubbed over lacquer surface for 20min.Lacquer should not lift from surface and cotton wool shall remain colorless. B ) Flexibility test: The tube was folded in such a manner that internal lacquer surface is outside. The lacquer coating should not be peeled off when the folded position is rubbed with finger . 3) LACQUER COMPATIBILITY TEST : 10 tubes are taken for the test. Product was filled and crimped subjected to 45 ⁰ C for 72hr.Tubes were allowed to cool and cut lengthwise . A) Product compatibility: Content should not show any discolorations or change in colour or gas formation. B) Lacquer compatibility: Lifting or peeling of lacquer is checked. OTR for packaging materials
Oxygen transmission rate (OTR) is the measurement of
the amount of oxygen gas that passes through a substance over a given period.
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