Phase 0 Phase 1 Phase 2 Phase 3 Phase 4

Pre clinical Clinical phase Therapeutic Theraptuic Post marke Synonym

Microdosing excploratory Confirmatory survelliacne
Animal Healthy Diseases Disease volunteers Type
volunteers
10-30 30-300 300-3000 No of
NCE/NME INDA NDA(Branded Non imp
Investiagonatol generic proportiarty
/ANDA(generic /Non
PropRITARY) generic BE
STUDIES NO CLINCAL
TRIALS
Screening Safety Safety and Efficacy Efficacy and safety ADR PV Purpose
Grignard
Wolff kishner
Clemmeson
Kolbe
Wurtz
Hoffmann broamide
Fittig
Wurtz fittig
Reimer Tiemann

Primary alchol ALDEHYDE

Secondary Ketone
Tertitrary (Na2cr2o7,k2cr2o7,Kmno4 ,Cro3) Alkene Ketone
 CDL:Kolkata
CDRI: Luckhnow
IVRI:Izzatnagar
Disulifram
Isomerism
• EZ
• RS
• Syn anti
• Dextro laevo
• DL
• cis trans(Gemoterical)
• Functional
• Positional
• Tautomers (Enol lactam lactim)
• Metamers
• Optical
• Meso
• Diaseteromers
• Atropisomerism
• Chain
• Staggered eclipsed
• Chair >twist boat >boat> half chair
 Pharm enginerring

• Drying
• Mixing
• size reduction
• size sepration
• filtraton
• centrifugation
• Flow of fluid
• Distilaation
• Evaporation
sem 1 analysis
• Mohr
• Volhard
• Fajan
• Ostwalds ripening
• Redox titration
• Acid base curves
Night blindness
All tests (Biochem,Cognosy)

Folin ciocolateau Tyrosine

Drug Category Subcategroy Chemica Biological Synonym Miscellaneous Use

Aloe Glycosides Anthraquinon Aloin Mussabar

e/C glyco Barbaloin kumari
BIOPHARM(BCS CLASS )
• Amorphous
• Crsytalline
Energy
• Low
Solublity
• Low
Stability
• HIGH
• High MP

4 causes of Non linearity

Michaelis menten
• Km=Vmax • Km<Vmax
• Km>V max • Zero
• Mixed
• First