APTIZOOOM

The alimentary canal or

Digestive System
gastrointestinal (GI) tract
digests & absorbs food

Alimentary canal –
mouth, pharynx,
esophagus, stomach,
small intestine & large
intestine

Accessory digestive
organs – teeth, tongue,
gallbladder, salivary
glands, liver & pancreas
Phases of digestion
Ingestion- taking food in
Propulsion- moves food through
tract
Mechanical digestion- physical
chewing, mixing, churning
Chemical digestion- catabolism/
breakdown of polymers into
monomers by enzymes
Absorption- passage of digested end
products across wall into blood
Defecation- eliminates indigestible
substances and other wastes
from body via anus in form of
feces
GI tract: Motility

Peristalsis Segmentation
Stomach: structure
 Stomach: digestion and emptying

Muscularis
• additional oblique muscle layer for churning and
mixing
Why doesn’t the stomach digest itself?

 Thick coating of alkaline mucus

 Tightly joined epithelial cells
 Damaged cells are quickly replaced
 (Completely renewed every 3-6 days)
Accessory organs

 Liver
 Gallbladder
 Pancreas
Functions of Liver
Functions of the Liver
Gall bladder, Pancreas and common bile duct
FUNCTIONS OF BILE

 Emulsification* of fat
 Stimulation of peristalsis
 Provides alkaline medium in intestine
These three functions play important role in digestion…

 Excretion of cholesterol
In humans, roughly 500 mg of cholesterol are converted to bile acids and eliminated in bile every day. This
route for elimination of excess cholesterol is important in situations of massive cholesterol ingestion.
http://www.vivo.colostate.edu/hbooks/pathphys/digestion/liver/bile.html

*Emulsification
1. The process of making an emulsion, allowing fat and water to mix.
2. The breaking down of large fat globules in the intestine into smaller, uniformly
distributed particles, largely accomplished through the action of bile acids, which lower
surface tension.
Pancreatic juice

 1200-1500ml produced daily

 Mainly water
 Enzymes
 produced in inactive form
 Active forms are trypsin, carboxypetidase, chymotrypsin,
 Produced in active form
 amylase, lipase, and nucleases
 Electrolytes
 bicarbonate ions- helps to neutralize acidic chyme
 Small Intestine major digestive organ

 Longest part of alimentary canal

 (3-6 hour journey)
 3 subdivisions
 1) duodenum
 shortest but lots going on
 Hepatopancreatic ampulla- bile duct and main pancreatic
duct enter
 2) jejunum
 middle portion
 3) ileum
 last part joins large intestine at ileocecal valve
Modifications

 Highly modified for absorption

 long length and 3 structural modifications
 Increase surface area to 200m2
 1) circular folds (plicae circulares)
 2) villi
 3) microvilli
Small Intestine: Internal
Structure and Function
Large Intestine: Structure
Bacterial flora

 Most bacteria are killed by stomach acid or enzymes

 Some survive
 Ferment indigestible carbohydrates (cellulose and others)
 Release acids and gases (about 500ml/day)
 Also release B complex vitamins and most of the body’s
vitamin K need (for clotting)
Food: Digestion and Metabolism
Food: Digestion and Metabolism
 What Is APTIZOOOM?

A polyherbal formulation - natural appetite

stimulant containing appetizers & digestives
 Indications of APTIZOOOM–

• Anorexia due to indigestion, any disease or drugs

• Slow growth in children due to poor appetite

Appetite means a desire for food

Anorexia is the symptom of poor appetite whatever the cause
HOW DOES APTIZOOOM WORK?

APTIZOOM stimulates appetite and promotes digestion

by mediating through two possible modes:
 Stimulation of liver to secrete more bile enriched in
bile acids
 Stimulation of enzyme activities of both pancreatic
and intestinal origin
HOW DOES APTIZOOOM WORK?
WHAT IS THE COMPOSITION OF APTIZOOOM?
Each 5 ml contains

Ingredients Qty.
Extract
SHATAVARI (Asparagus racemosus) 100 mg
VIDANGA (Embelia ribes) 50 mg
GAJA PIPPALI (Scindapsus officinalis) 25 mg
BHRINGARAJ (Eclipta alba) 25 mg
SHUNTHI (Zingiber officinale) 25 mg
AJMODA (Apium graveolens) 15 mg
TWAK (Cinnamomum cassia) 15 mg
TAMALPATRA (Cinnamomum iners) 15 mg
PIPPALI MOOL (Piper longum) 15 mg
FLAVOURED SYRUPY BASE q.s
 WHAT IS THE MECHANISM OF ACTION OF
VARIOUS INGREDIENTS OF APTIZOOOM?

Important ingredient Action

 SHATAVARI  Anti-oxidant
 VIDANGA  Anthelminthic#
 BHRINGARAJ  Digestive
 Prokinetic^
 SHUNTHI  Digestive
 Appetizer
 AJMODA  Anti-spasmodic
 Anti-flatulent
 TWAK  Carminative*
 TAMALPATRA  Carminative
 PIPPALI MOOL  Digestive
 Appetizer
 Anthelminthic
*Carminative: An agent that prevents or relieves flatulence (gas in the gastrointestinal tract)
#Anthelmintic: expelling or destroying parasitic worms especially of the intestine
^Gastrokinetic, or prokinetic, is a type of ingredient which enhances gastrointestinal motility
Asparagus racemosus Embelia ribes Scindapsus officinalis Apium graveolens

Eclipta alba Zingiber officinale Cinnamomum cassia Cinnamomum iners

COMPETITIVE ADVANTAGE OF APTIZOOOM OVER
SOME LEADING PREPARATIONS?

 APTIZOOOM syrup is a blend of appetizers and digestives

spices with digestive stimulant action

 APTIZOOOM has stimulatory effect on the secretions of GI

tract, liver and pancreas.

 Unlike the conventional appetite stimulants, APTIZOOOM is

totally safe and does not cause side effects like drowsiness
WHAT IS THE DOSAGE & PRESENTATION
OF APTIZOOOM?

DOSAGE
 Children (below 10 years): 5ml twice/ thrice a day for 4
weeks
 Adults: 15ml twice a day for 4 weeks
 To be taken half an hour before meals

PRESENTATION
 Bottle of 200 ml
WHO ARE THE TARGET AUDIENCE FOR APTIZOOOM?

 - General Practitioner
 - Physician
 - Pediatricians
Thanks