A STUDY OF INCIDENCE OF

HYPOGLYCEMIA AND HYPOCALCEMIA IN

INFANTS BORN TO DIABETIC MOTHERS
AND A CORRELATION WITH MATERNAL
THIRD TRIMESTER GLYCEMIC CONTORL
T.PARDHA SARADHI
1ST YEAR PEDIATRICS PG
INTRODUCTION
• INCIDENCE OF ANATOMICAL AS WELL AS METABOLIC
COMPLICATONS IN INFANTS BORN TO DIABETIC MOTHER ARE
INCREASING

• MOST OF THEM ARE DUE TO POOR GLYCEMIC CONTORL

DURING THIRD TRIMESTER

• HYPOGLYCEMIA IS SEEN IN 25-40% OF BABIES BORN TO

DIABETIC MOTHER
STRUCTURAL COMPLICATIONS METABOLIC COMPLICATIONS
• NEURAL TUBE DEFECTS • HYPOGLYCEMIA
• DUODENAL ATRESIA • HYPOCALCEMIA
• CARDIOVASCULAR DISEASES • HYPERBILIRUBINEMIA

• POOR GLYCEMIC CONTORL IN 1ST • POOR GLYCEMIC CONTORL IN 3RD

TRIMESTER TRIMESTER
•AIM
• CORRELATION BETWEEN MATERNAL 3RD TRIMESTER HBA1C
VALUE IN DIABETIC MOTHER AND INCIDENCE OF
HYPOGLYCEMIA AND HYPOCALCEMIA IN BABIES BORN TO THEM

• MOTHERS HAVING FASTING BLOOD GLUCOSE MORE THAN

90mg/dl AND POSTPRANDIAL BLOOD SUGAR MORE THAN
120mg/dl WERE DIAGNOSED TO HAVE DIABETES
• STUDY DESIGN……..COHORT STUDY
• PLACE OF STUDY…..GOVERNMENT SIVAGANAGAI MEDICAL
COLLEGE AND HOSPITAL
• SAMPLE SIZE ………..100
• DURATION OF STUDY…..1 YEAR
• ETHICAL CLEARANCE…..YET TO APPROVE
• CONSENT……..INFORMED AND WRITTEN CONSENT FROM
MOTHER
• INCULSION CRITERIA
• ANTENATAL MOTHERS WITH GESTATIONAL AND PRE
GESTATIONAL DIABETES AND NEONATES BORN TO THEM
• EXCULSION CRITERIA
1. ALL PRETERM AND IUGR NEONATES BORN TO DIABETIC MOTHER
2. NEONATES WHO HAD BIRTH ASPHYXIA
3. NEONATES WHO HAD CONGENITAL ANAMOLIES WHICH SHOWED
POOR 1ST TRIMESTER GLYCEMIC CONTORL
4. NEONATAL SEPSIS
WORK UP
• BLOOD SAMPLE FROM 3RD TRIMESTER MOTHER FOR HBA1C
ESTIMATION

• BLOOD SAMPLES FROM BABY AT 1 HOUR,2 HOUR,6 HOUR,12

HOUR,24 HOUR FOR ESTIMATING BLOOD SUGAR VALUES BY
GLUCOSE OXIDASE TEST

• BLOOD SAMPLE FOR ESTIMATION OF IONISED CALCIUM BY ION

SELECTIVE ELECTRODE TECHNIQUE AT 24TH HOUR OF LIFE
• BLOOD SUGAR LESS THAN 45mg/dl IS CONSIDERD AS
HYPOGLYCEMIA AND IT IS TAKEN AS CUT OFF VALUE AND SERUM
IONISED CALCIUM LEVLES LESS THAN 4mg/dl WAS TAKEN AS
HYPOCALCEMIA CUT OFF VALUE

• HBA1C LESS THAN 6.1 IS TAKEN AS HAVING GOOD GLYCEMIC

CONTORL AND IT IS TAKEN AS CUT OFF VALUE

• HBA1C LEVLES OF MOTHER CAN BE USED AS SCREENING MARKER

TO MONITOR,ANTICIPATE HYPOGLYCEMIA EPISODES OF NEWBORN
STATISTICAL ANALYSIS
• DATA COLLECTED AND ENTER IN MICROSOFT EXCEL AND
ANALYSED USING SSPS SOFTWARE

• PERCENTAGES,PROPORTIONS AND MEAN VALUES ARE

DERIVED

• ONE WAY CHI-SQUARE TEST SHOLUD BE USED

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