Professional Documents
Culture Documents
021 - Abstract 021 - HBV Gentotypes
021 - Abstract 021 - HBV Gentotypes
By
Orabueze Ibuchukwu N.
INTRODUCTION
Hepatitis B virus infection is highly contagious and poses a serious threat to public health
and security.
Its infectivity rate is 50-100 times more than that of HIV and 10 times higher than that of
HCV.
The burden of disease is highest in low-and-middle income countries with associated
significant morbidity and mortality.
The virus has ten genotypes which have distinct geographical distribution.
Their age ranges from 20 to 89 years and the mean age was 37.33±11.70 years.
A 28 54.9
C 3 5.9
E 20 39.2
Total 51 100
DISTRIBUTION OF HEPATITIS B VIRUS SUB-GENOTYPES
E = 20 ND ND 100
Lower Upper
Contact with a known HBV patient .160 1.309 .015 0..903 1.173 .090 15.257
Family History of Liver disease 18.521 87.668 .870 0.598 896.50 .060 10.315
MULTIVARIATE LOGISTIC REGRESSION RESULT OF
PREDICTIVE FACTORS OF HBV
Multiple Sexual partners .702 2.749 1.879 0.035** 2.019 -.465 8.771
Frequent use of condom .286 .759 .142 0..706 1.332 .301 5.895
Sexually Transmitted Infection -.735 .853 .742 0.389 .479 .090 2.553
These differences maybe due to: study population, sample size and migration.
A switch in genotype can occur in chronic HBV patients and this is mainly seen
in people with mixed genotypes.
Phylogenetic analysis showed that the sequences clustered around Africa, Asia,
and America, suggesting that these patients may have contacted this infection
outside or within Nigeria
The associated risk factors reported agree with previous studies.[5-7]
CONCLUSION
Hepatitis B virus genotypes and sub-genotypes are important because they
can influence the clinical outcome, treatment response and transmission route
In this study, the genotypes detected were A, C, and E.
The factors associated with increased risk for HBV transmission were
sharing sharps/clippers, education, and having multiple sexual partners.
Overall, this calls for increased awareness and targeted preventive measures
that will help actualise the 2030 HBV vaccine driven elimination goal.
REFERENCES
Uche EI, Chukwukaodinaka NE, Akinbami AA, Adeyemi OI, Hassan AO, Bamiro RA et
al. Common hepatitis B virus genotypes among blood donors in Lagos, Nigeria. N Post
Med J. 2022; 29: 228-235.
Opaleye OO, Akanbi OA, Osundare FA, Wang B, Adesina O, Oluremi AS, et al.
Characteristics of hepatitis B and D virus infections among HIV-positive individuals in
South-western Nigeria. Virol J. 2021; 18(1): 20.
Ambachew H, Zheng M, Pappoe F, Shen J, Xu Y. Genotyping and sero-virological
characterization of hepatitis B virus (HBV) in blood donors, Southern Ethiopia. PLoS
One. 2018; 13(2): e0193177.
Ito K, Yotsuyanagi H, Yatsuhashi H, Karino Y, Takikawa Y, Saito T, et al. Risk factors for
long-term persistence of serum hepatitis B surface antigen following acute hepatitis B
virus infection in Japanese adults. Hepatology. 2014; 59: 89–97.
THANK YOU
FOR
LISTENING