REVIEW ON CREAM AS TOPICAL

DRUG DELIVERY SYSTEM

By : Siddhant Sanjay Hagavane
Final Year ( B.pharm )
 CONTENT
1.Introduction
2.Advantages and Disadvantages
3. Type of skin cream
4.General ingredients used in skin creams
5.Methods of preparation of creams
6.Evaluation parameters of creams
7.Applications
8.Conclusion
9.References
10.Summary
 INTRODUCTION

● The word ‘Cosmetic’ derived from a Greek word – ‘kosmesticos’ that means to adorn. From that
time any actually stems from its use in Ancient Rome.

● Cosmetics products have been generally defined as “articles intended to be applied to the human
body by being rubbed, proud, sprinkled, or sprayed for cleansing, promoting, attractiveness,
beautifying, or altering the appearance”.
 ADVANTAGES &
DISADVANTAGES
● Advantages :
1.It is the easiest way to deliver a drug.
2.It does not show the side effect on the other body organ.
3.Convenient and easy to apply.
4.It does not show the side effect on the other body organ.
5.It can slow down the sign of aging.
6.Less greasy compared to ointment.
● Disadvantages :
1.Skin irritation.
2.Possibility of allergic reactions.
3.Stability is not as good as ointment.
4.Some drugs show low penetrable through the skin.
5.They are less hydrophobic than other semisolid preparation,
so risk contamination is high than others.
 Type of skin
creams :
● 1.Oil-in-Water (O/W)

● 2.Water-in-Oil (W/O)
 CLASSIFICATION OF CREAMS
● A. All the skin creams can be classified on different basis :

1. According to function, e.g. cleansing, foundation, massage, etc.

2. According to characteristics properties, e.g. cold creams, vanishing creams.

3. According to the nature or type of emulsion.

B. Types of creams according to function, characteristic properties and type of emulsion :

1.Make-up cream : ( o/w emulsion )

a. Vanishing creams :
b. Foundation creams :

2. Cleansing creams : ( w/o emulsion )

3. Winter creams :
4. All purpose creams and general creams.
5. Night cream or massage creams.
6. Skin protective creams.
7. Hand and body creams.
 GENERAL INGREDIENTS USED IN
SKIN CREAMS
● Water.

● Oil, fats and waxes.

● Mineral oil.

● Glyceride oil.

● Vegetable oil.

● Waxes.

● Fats.
● Lanolin.

● Colours.

● Emollients.

● Humectants.

● Perfumes.

● Vitamins.

● Preservatives.
 METHOD OF PREPARATION
1. Preparation of o/w emulsion cream :

The oil soluble components and the emulsifier are taken in one beaker and melted
Bath at 75 C. and in other beaker water , preservatives and water-soluble components are
taken and melted at 75C. After heating, the oil phase was taken in mortar and pestle and
slowly the water phase was added and triturated till clicking sound was heard. Finally,
when the temp cools down, perfuming agents or preservatives are added. In this
preparation, water content will be more than the oil.
2. Preparation of w/o emulsion creams :

The oil soluble components and emulsifier are taken in one beaker and melted at 75C. And
in another beaker water and water-soluble components are taken and melted at 75C. After
melting, water phase are taken mortar and pestle and slowly oil phase was added and
triturated till clicking sound was heard. And when the temp of the cream will get cooled,
then the perfuming agent are added. In this preparation, water phase will be less and oil
phase will be more.
 EVALUATION PARAMETERS OF
CREAMS
1. Determination of pH.
2. Physical appearance.
3. Saponification.
4. Spreadability.
5. Acid value.
6. Viscosity.
7. Homogeneity.
8. Removal.
9. Dye test.
10. After feel.
11. Type of smear.
12. Irritancy study.
13. Accelrated stability study.
 APPLICATIONS
1. Skin softening.

2. Smoothing.

3. Cooling.

4. Moisturizing.

5. Antiseptic.

6. Cleaning.

7. Astringent.

8. Antifungal
 CONCLUSION
Creams are semisolid formulations widely acceptable by the society. The skin is the most
accessible part of the body and such is also highly vulnerable to injuries. In case of cuts,
burns, and wounds, topical formulations such as creams are the most preferred for
treatment. Research and development for the formulations for the formulation of
pharmaceutical creams for wound healing healing purpose has grown in recent decades
owing to its obvious benifits. With the progress in the pharmaceutical field and industry. It
is assured that pharmaceutical creams will still be an interesting and appealing area of
research for years to come.
 REFERENCE
1. 1. Sahu T, Patel T, Sahu 5, Gidwani B, "Skin Cream as Topical Drug Delivery System: A
Review" Journal of Pharmaceutical and Biological Sciences, Published by Atom and Cell
Publishers, ISSN: 2320-1924.

2. Rai P, Proudly AP, Das S, Pharmaceutical Creams and their use in wound healing: A Review,
from Journal of Drug Delivery and Therapeutics.

3. . Garg T, Rath G, Goyal AK. Comprehensive review on additives of topical dosage forms for
drug delivery. Drug Deliv. 2015;22(8):969-987

4. Khar R.K, Vyas.S.P ,Ahamad. F.J, jain. G.K the Theory And Practice of Industrial Pharmacy
CBS publication, Fourth Edition 2013; 652.
 SUMMARY
● Creams is the vehicles and delivery systems for dermatological products.

● Creams are emulsions, either oil-in-water ( O/W ) or water-in-oil ( W/O ).

● It is the convenient to apply.

● Stability is not good as ointment. All the skin creams can be classified on different
basis such as according to its function and characteristics properties e.g. makeup
creams, foundations cream, winter creams, night cream.

● General ingredients used in skin creams

THANK
YOU.