Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

Topic- Pharmaceutical Nanotechnology And It’s Application

Department of Pharmaceutical Science and Technology

Presented to: Presented by:

Mr. Ramashankar Dubey Shahil Ali (2021091051)
Guest faculty at Department of Pharmaceutical Shashank Mishra (2021091052)
Science and Technology Shivam Sharma (2021091053)
Shreya Gupta (2021091054)
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

Index:
1. Abstract
2. Objective
3. Introduction
4. Material Used
5. Methodology
6. Result & Discussion
7. Conclusion
8. References
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

ABSTRACT
Nanotechnology is the study of extremely small structures, having size of 0.1 to 100 nm.
Nano medicine is a relatively new field of science and technology. Brief explanation of
various types of pharmaceutical nano systems is given. Classification of nano materials
based on their dimensions is given. An application of Nanotechnology in various fields
such as health and medicine, electronics, energy and environment, is discussed in detail.
Applications of nano particles in drug delivery, protein and peptide delivery, cancer are
explained.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

OBJECTIVE
Here are some key objectives of pharmaceutical nanotechnology:

1. Enhanced Drug Delivery:

2. Targeted Therapy:
3. Controlled Release:
4. Improved Drug Efficacy:
5. Diagnostic Applications:
6. Personalized Medicine:
7. Reduced Toxicity:
8. Combination Therapies:
9. Stability Enhancement:
10. Non-Invasive Administration:
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INTRODUCTION
Advancement in the field of nanotechnology and its applications to the field of
medicines and pharmaceuticals has revolutionized the twentieth century.
Nanotechnology is the study of extremely small structures. The prefix “nano” is a Greek
word which means “dwarf”. The word “nano” means very small or miniature size.
Nanotechnology is the treatment of individual atoms, molecules, or compounds into
structures to produce materials and devices with special properties. Nanotechnology
involve work from top down i.e. reducing the size of large structures to smallest
structure e.g. photonics applications in nano electronics and nano engineering, top-
down or the bottom up, which involves changing individual atoms and molecules into
nanostructures and more closely resembles chemistry biology. Nanotechnology deals
with materials in the size of 0.1 to 100 nm; however it is also inherent that these
materials should display different properties such as electrical conductance chemical
reactivity, magnetism, optical effects and physical strength, from bulk materials as a
result of their small size.
Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

History of Nanotechnology:
The development in the field of nanotechnology started in 1958 and the various
stages of development have been summarized in Table 1.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

TYPES OF PHARMACEUTICAL NANOSYSTEMS

 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

MATERIALS USED
Materials commonly used in pharmaceutical nanotechnology include:
1. Lipids
2. Polymers:
3. Gold Nanoparticles
4. Silica Nanoparticles
5. Carbon Nanotubes
6. Dendrimers
7. Nanocrystals
8. Iron Oxide Nanoparticles
9. Proteins and Peptides
10. Hydrogels
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

METHODOLOGY
The physicochemical characteristics of the polymer as well as the selected drug
determine the suitable method for the preparation. Nanoparticles mainly have been
synthesized by different methods including dispersion of pre-formulated polymers, co-
acervation of hydrophilic polymers and polymerization of monomers. Other techniques
have been mentioned in the literature for production of nanoparticles including
supercritical fluid technology and particle replication in non-wetting templates.
1. Dispersion of preformed polymers:
2. Solvent evaporation method:
3. Spontaneous emulsification:
4. Double emulsion and evaporation method:
5. Salting out method:
6. Emulsions–diffusion method:
7. Solvent displacement method:
8. Coacervation or ionic gelation method:
9. Polymerization method:
10. Nano spray drying:
11. Supercritical fluid technology:
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

APPLICATIONS OF NANOTECHNOLOGY
The different fields that find potential applications of nanotechnology are as follows: a.
Health and Medicine b. Electronics c. Transportation d. Energy and Environment e.
Space exploration Nanotechnology in health and medicine Even today various disease
like diabetes, cancer, Parkinson’s disease, Alzheimer’s disease, cardiovascular diseases
and multiple sclerosis as well as different kinds of serious inflammatory or infectious
diseases (e.g. HIV) constitute a high number of serious and complex illnesses which are
posing a major problem for the mankind. Nanomedicine is an application of
nanotechnology which works in the field of health and medicine. Nano-medicine makes
use of nano materials, and nano electronic biosensors. In the future, nano medicine
will benefit molecular nanotechnology. The medical area of nano science application
has many projected benefits and is potentially valuable for all human races. With the
help of nano medicine early detection and prevention, improved diagnosis, proper
treatment and follow-up of diseases is possible. Certain nano scale particles are used as
tags and labels, biological can be performed quickly, the testing has become more
sensitive and more flexible.
Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

RESULT & DISCUSSION

Nanotechnology is now widely regarded as the enabling technology of the 21st century.
Today nanostructured materials and nanotechnology techniques are being used to produce
better composite materials, materials with enhanced catalytic activity, hardness and scratch
resistance, and a wide range of consumer products (such as cosmetics and sunscreens) that
improve human life.
Nanotechnology enables precise manipulation of materials at the nanoscale, typically 1-
100 nanometers.
Pharmaceutical nanotechnology employs nanoparticles for drug delivery, diagnostics, and
therapy.
Methods include bottom-up (chemical synthesis) and top-down (particle engineering)
approaches.
Nanoparticles can encapsulate drugs, enhance solubility, target specific tissues, and
improve pharmacokinetics.
Applications range from cancer therapy to personalized medicine.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

CONCLUSION
Nano materials have increased surface area and nano scale effects, hence used as a
promising tool for the advancement of drug and gene delivery, biomedical imaging and
diagnostic biosensors. Nano materials have unique physicochemical and biological
properties as compared to their larger counterparts. The properties of nano materials
can greatly influence their interactions with bio molecules and cells, due to their
peculiar size, shape, chemical composition, surface structure, charge, solubility and
agglomeration. For example, nano particles can be used to produce exceptional images
of tumor sites; singlewalled carbon nanotubes, have been used as high-efficiency
delivery transporters for biomolecules into cells. There is a very bright future to nano
technology, by its merging with other technologies and the subsequent emergence of
complex and innovative hybrid technologies.
 Madan Mohan Malaviya University Of Technology, Gorakhpur U.P.

REFERENCES
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