MINISTRY OF EDUCATION

University of Technology ( Yatanarpon Cyber City )

Faculty of Advanced Materials Engineering ( UT-YCC )

Study on synthesis and characterization of cerium

oxide nanoparticles by surfactant-assisted
precipitation method

Supervised by ◊ First Seminar ◊ Presented by

Dr . Saw Mya Ni Wai Yan Phyo (6AME-27)

Date -1.7.2020
 Contents
 Introduction
 Raw materials & Equipment
 Procedure
 Process Variables
 Characterization Techniques
 Results & Discussion
 Applications
 Conclusion
 Reference
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 Introduction

 Nanoceria can reversibly bind oxygen and shift oxidation states (Ce3+ /Ce4+ )
depending on the conditions .
 In recent years, CeO2 nanoparticles have been developed as a therapeutic for
oxidative stress diseases due to their catalytic antioxidant properties .
 Different synthesis methods can produce cerium oxide nanoparticles of varying
size, morphology, and agglomeration . In general, using a polymer or surfactant
during synthesis results in lowered agglomeration of CeNPs in bio-relevant
solutions .

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 Introduction

Figure 1. A depiction of some of the causes of oxidative stress and the redox action of CeNPs
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 Raw Materials and Equipment

Raw Materials Equipment

 Cerium nitrate hexahydrate
[ Ce(NO3)3 . 6H2O ]
 Sodium hydroxide [ NaOH ]
 Polyvinyl pyrrolidone [ PVP ]
 Ethanol [ C2H5OH ]
 Deionized water
 Magnetic stirrer
 Overhead stirrer
 Hot air oven
 Centrifuge machine
 Muffle furnace
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 Procedure
0.1M Ce(NO3)3.6H2O
+
0.05M PVP

Stirring for 10min

0.03M NaOH
until pH>9
Yellow Precipitate
Stirring for 90 min
Pale-Yellow Slurry

Centrifugation

Washing

Drying at 110⁰C Calcination at 600⁰C CeO2 Nanoparticles

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 Process Variables

Ce(NO3)3.6H2O NaOH PVP Calcination

Sample
Concentration Concentration Concentration Temperature

A 0.1 M 0.3 M 0.05 M 600⁰C

B 0.1 M 0.3 M 0.05 M 600⁰C

C 0.05 M 0.3 M 0.05 M 500⁰C

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 Characterization Techniques

 The structural, morphological and optical studies of cerium oxide nanoparticles

were characterized by X-Ray Diffraction (XRD), Scanning Electron Microscopy
(SEM), Fourier Transform Infrared (FTIR) Spectroscopy and Ultraviolet-visible
Spectroscopy ( UV-vis ) .

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Results & Discussion

Fig 2. XRD pattern of CeO2 particles 9

 Results & Discussion

 XRD profile confirmed that the high intensity peaks were observed at 2θ values
of 28.53, 33.09, 47.5, 56.26 respective to the 111, 200, 220, 311 crystal planes .
 The diffraction peaks in these XRD spectra indicates the pure cubic fluorite
structure .
 Crystallite size was obtained by using the Debye’s Scherrer equation:

 The crystallite size was found to be in the range from 9 -16 nm.

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 Results & Discussion

Fig 3. SEM image of CeO2 nanoparticles

 Nanosized spherical shaped cerium oxide nanoparticles obtained was confirmed

by SEM image .
 The mean size of the nanoparticles varies from 18 – 30.4 nm .
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Results & Discussion

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Fig 4. FTIR spectrum of CeO2 nanoparticles

 Results & Discussion

 The FTIR spectrum of CeO2 was recorded in the wave number range of 400 –
4000 cm-1 .
 The bands at 1622.71 and 3375.80 cm-1 represent the water and hydroxyl
stretches, respectively.
 The band at 1384.23 cm-1 represents N-O stretch due to the presence of nitrate .
 The absorption band at wave number 550.84 cm-1 represents the Ce-O stretch .

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Results & Discussion

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Fig 5. UV-vis absorbance spectra of CeO2 nanoparticles

 Results & Discussion

 UV-visible absorbance spectrum of CeO2 was recorded for the nanoparticles

dispersed in water . Here, water is used as a blank .
 A strong absorption below 400 nm was observed .
 A very well defined absorbance peak was observed around 325 nm for the
synthesized CeO2 nanoparticles .

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Industrial Uses
Applications
 Glass polishing
 Catalytic convertors for removing toxic gases
 Solid oxide fuel cells
 Electrochromic thin-film applications
 Sensors and catalysts
 Filler for lithium polymer battery

glass polishing, catalytic convertors for removing toxic gases, solid oxide fuel cells, electrochromic thin-film applications, sensors and catalysts

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Biomedical Fields
Applications
 Anti-inflammatory & antiapoptotic activity
 Reducing ROS & RNS
 Cancer therapy, especially ovarian cancer
 ROS related diseases like cardiac disease
 Neurodegenerative diseases such as Alzhimer’s disease
 Treating tumor
 Tissue regeneration and wound healing

glass polishing, catalytic convertors for removing toxic gases, solid oxide fuel cells, electrochromic thin-film applications, sensors and catalysts

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 Conclusion

 Cerium oxide nanoparticles can be prepared by surfactant-assisted

precipitation method using NaOH as a precipitation agent and PVP as a
surfactant .
 The morphology of CeO2 nano particles was highly dependent on the
surfactant . The well dispersed spherical shape with size range of 18 – 30.4 nm
was observed through PVP assisted method .
 We can anticipate that over the next decade, CNPs will become ‘the global
equivalent of an aspirin for oxidative stress-associated diseases’ .
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 References

1. Chelliah, M., Rayappan, J., Krishnan, U. (2012) ‘Synthesis and Characterization of

Cerium Oxide Nanoparticles by Hydroxide Mediated Approach’, Applied Science 12
(16) : 1734-1737.
2. Das, S., Dowding, J. et al. (2013) ‘Cerium oxide nanoparticles: applications and
prospects in nanomedicine’, Nanomedicine 8(9) : 1483–1508 .
3. Nyoka, M. et al. (2020), ‘Synthesis of Cerium Oxide Nanoparticles Using Various
Methods: Implications for Biomedical Applications’, Nanomaterials : 1-21 .
doi:10.3390/nano10020242

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THANK YOU
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