The Primary Health Centre (PHC) is the basic structural and functional unit of the public health services

1st line unit for health care.. Main services are immunization basic curative services maternal & child health services

 Mech..

peptidoglycan

transpeptidase

penicillin

 Penicillin can act on both gram +ve and ve bacteria but less on gram ve because..

Benzylpenicillin Procain benzylpenicilline Benzathine benzylpenicilline Ampicillin & Amoxycillin coxacillin

 Penicillin G group Mainly used as drug of choice for Pneumococcal pneumonia, empyema, pericarditis Strept infections (pharyngitis, otitis media) Subacute endocarditis caused by strepto. Viridans, pyogenes Meningitis caused by pneumococci, meningococci Gonorrhea, syphilis Anthrax Diphtheria, gas gangrene

 Contain = procain local anaesthetic (to decrease pain at the IM inj. Site) + benzylpenicillin

 They are synthetic penicillin compouns. Mainly used for.. Meningitis (group D strepto.) drug of Respiratory tract infection choice STD (gonorrhea) UTI Cholecystitis Septicemia Subacute bacterial endocarditis

 Mech same as penicillin. But act at different binding protein of the enzyme So may useful against the penicillin resistant bacteria

 1st = more active against gram +ve Use is mainly 2 to penicillin less against ve (cephalexin) use nd = gram ve > 1st generation 2 gram +ve < 1st (cefuroxime) 3rd = most active against gram ve > 2nd > 1st poor against +ve 4th = for serious gram ve infections
nd

trimethoprim

cotrimoxazole
sulfamethoxazole

 Mech PABA
SULFFONAMIDE FOLATE SYNTHASE

DHFA
TRIMETHOPRIM DIHYDROFOLATE REDUCTASE

THFA

Acute uti Respi. Tract infection Diarrhoea Pneumocystis jiroveci Chancroid

 Mech. Normally protein synthesis by the bacteria.

30s

50s

 Amynoglycoside bind to 30s subunit or 30s50s interface. So there is disturbance in function of ribosome.. Formation of different protein.. Also increase permeability of membrane. Amino acid, ions, protein are leaked out. Bactericidal activity.

 Mainly for gram ve bacteria. Kanamycin It is used for.. and Prevention and treatment of respi. Tract Amikacin infection of AIDS patient, in ICU may Pseudomonas, proteus, klebsiella infecton (uti, be stored to abscesses, middle ere infection) pneumonia,tackle Gram ve the grammeningitis negative Subacute bacterial endocarditis (gentamycin + organisms. erythromycin)

 Mech. Same as aminoglycoside.

 1st choice of drug for Atypical pneumonia Whooping cough Chancroid 2nd choice of drug for. Legionnaires pneumonia Urogenital tract infection (Chlamydia trachomatis) Penicillin resistant staphylococcal infection

In penicillin contra indicated cases of tonsillitis, Pharyngitis, cellulitis

 Mech. Inhibition of cell wall synthesis. Mainly act on enterococcal fecalis, Methicillin resistant strepto aureus.

 In the penicillin and cephalosporin resistant bacterial infection. Enterococcaal endocarditic Meningitis (vancomycin + ceftriaxone / cefotaxime )

 Mech

USE typhoid Uti Gonorrhea Respi. Infection Conjunctivitis bacterial gastroenteritis

 The common Anti tubercular drugs needed are Isoniazid/INH(H), In pregnant Rifampicin(R), woman S and Z Are Pyrazinamide(Z), contraindicated. Ethambutol(E), Streptomycin(S)

 There are different regimens of 6-9 months duration for diiferent categories in DOTS All Regimens have an (i) initial intensive phase,lasting for 2-3 months, (ii) continuation phase

 New sputum smear positive pulmonary TB. New sputum smear negative(seriously ill) pulmonary TB. New cases (seriously ill) of extra pulmonary TB. TREATMENT Initial phase=For 2 months,H3R3Z3E3 Continuation phase=For 4 months,H3R3

 Treatment Failure,Relapse. TREATMENT Initial phase=For 2 months,H3R3Z3E3S3+ For 1 month,H3R3Z3E3 Continuation phase=For 5 months,H3R3E3

 Cases of Sputum smear negative(not seriously ill) Cases of Extra pulmonary TB(not seriously ill) TREATMENT Initial phase=For 2 months,H3R3Z3 Continuation phase=For 4 months,H3R3

 Dapsone Clofazimine Rifampicin

dapsone alone(100-200 mg daily ),duration depends on the type of leprosy)

Rifampicin,Dapsone,Clofazimine is introduced by WHO.

Rifampicin(600 mg once a month,supervised), Dapsone(100 mg daily, self administered), Clofazimine(300 mg once a month, supervised/50 mg daily self administered) only Rifampicin and Dapsone are used.