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Mictur3 Physiol
Mictur3 Physiol
Mictur3 Physiol
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Cortex Medulla
Collecting Duct
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GF
Kidney Tubule
TR
Peritubular Capillary
TA
Urine Excreted
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Glomerular Filtration
First step in urine formation 180 liters/day filtered Entire plasma volume filtered 65 times/day Proteins not filtered
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+ -
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15
10
9
Tubular Reabsorption
Water: 99% reabsorbed Sodium: 99.5% reabsorbed
Tubular Reabsorption
By passive diffusion By primary active transport: Sodium
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Lumen
Cells
Plasma
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Sodium Reabsorption
PUMP: Na/K ATPase Lumen Sodium
Cells
Potassium Plasma Chloride Water
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They are actively transported across the apical cell membranes of the epithelial cells Their active transport depends on the sodium gradient across this membrane All other steps are passive
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Filtered
Excreted
Reabsorbed
15
Rennin-AngiotensinAldosterone System
Stimulates Sodium Reabsorption in distal and collecting tubules Naturetic peptide inhibits In absence of Aldosterone, 20mg of sodium/day may be excreted Aldosterone can cause 99.5% retention
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Rennin-AngiotensinAldosterone System
Fall in NaCl, extracellular fluid volume, arterial blood pressure
Juxtaglomerular Apparatus Adrenal Cortex Lungs Helps Correct
Liver
Renin
+
Angiotensin Angiotensin
Converting Enzyme
Angiotensin
Aldosterone
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DIURETICS
ACE Inhibitors (Angiotensin Converting Enzyme): Cause loss of salt---> water follows Atrial Naturetic Peptide (ANP) also inhibits sodium reabsorption Osmotic diuretics: Are not reabsorbed
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Tubular Secretion
Protons (acid/base balance) Potassium
Organic ions
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Potassium Secretion
PUMP: Na/K ATPase Lumen Sodium
Cells
Potassium Plasma Chloride Water
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ECF Volume
Blood Pressure
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Descending limb
Highly permeable to water No active sodium transport
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Ascending limb
Actively pumps sodium out of tubule to surrounding interstitial fluid Impermeable to water
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300
450 600 750 900 1050 1200 1200
300
450 600 750
100
250 400 550
900
1050 1200 1200
700
850 1000 1000
THE OSMOTIC GRADIENT CONCENTRATES THE URINE WHEN VASOPRESSIN (ANTI DIURETIC HORMONE [ADH]) IS PRESENT Interstitial Fluid
300
450 600 750 900 1050 1200 1200 From Distal Tubule
Cortex
300
Collecting Duct
Medulla
850
1000
Pores Open
1100 1200
WHEN VASOPRESSIN (ANTI DIURETIC HORMONE [ADH]) IS ABSENT A DILUTE URINE IS PRODUCE Interstitial Fluid
300
450 600 750 900 1050 1200 1200 From Distal Tubule
Cortex
100
Collecting Duct
Medulla
100
100
Pores Closed
100 100
Renal Failure
Acute: Sudden onset, rapid reduction in urine output - usually reversible Chronic: Progressive, not reversible Up to 75% function can be lost before it is noticeable
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