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Sifat Dan Kerja Otot Jantung - CVS-K10
Sifat Dan Kerja Otot Jantung - CVS-K10
Sifat Dan Kerja Otot Jantung - CVS-K10
Departemen Fisiologi
Fakultas Kedokteran Universitas Sumatera Utara
The heart contracts, or beats, rhythmically as a result of action potential that it generate by itself autorhythmicity.
Bundle of HIS
Purkinjie Fibers
Two classes of cardiac muscle cells 1) Auto rhythmic cells : Specialized muscle cells of conducting system 2) Contractile cells
Pacemaker potential
ELECTRICAL PROPERTIES
Action potential in cardiac contractile cell Travels down T tubules Entry of small amount of Ca2+ from ECF Release of large amount of Ca2+ from sarcoplasmic reticulum Troponin - tropomyosin complex in thin filaments pulled aside Cross-bridge cycling between thick and thin filaments Thin filaments slide inward between thick filaments Contraction
Contraction
Conduction in AV node is slow, about 0.1 s (AV nodal delay) before excitation spreads to ventricles. From top of septum, depolarization spreads conducting Purkinje fibers to all parts of ventricles in the 0.08-0.1 s.
Activation anteroseptal region ventricular myocardium Activation major portion ventricular myocardium from endocardial surfaces Late activation posterobasal left ventricle and pulmonary conus
Starling's law of the heart or FrankStarling law = "energy of contraction is proportional to the initial length of cardiac muscle fiber." = relation between ventricular stroke volume and end-diastolic volume
The length-tension relationship in cardiac muscle is similar to that in skeletal muscle as the muscle is stretched, the developed tension increases to a maximum and then declines as stretch becomes more extreme.
Myocardial Contractility
Fungsi jantung
Syok Kardiogenik